Your question is unclear.
Please provide more information, and be as specific as possible.
- What do you want to accomplish?
- What have you already tried?
- What problems did you encounter?
Also, please be sure that you have included all relevant code and/or a link to the page in question.
First off, making a layout for a PHP-driven website is no different than making a layout for any other website - you use HTML and CSS. The bigger issue is what you want the layout to look like.
To try to answer part of your question, images can be "part of" hyperlinks simply by putting them inside the anchor element (just as you would with text), like so:
If you have a more specific question, please explain.
<a href="http://example.com/"><img src="image.png"></a>