After a fashion, yes.
Make the values comma delimited and parse the values into an open method, like:
Code:
<form name="URLlist">
<select name="droplist">
<option selected="selected" value=" ">Select a Destination!</option>
<option value="http://www.yoururl.com,_new">Your Discription</option>
<option value="http://www.yoururl1.com,_top">Your Discription1</option>
<option value="http://www.yoururl2com,yourframenamehere">Your Discription2</option>
</select><input type="button" value="go!" onclick="GotoURL(this.form)">
<script type="text/javascript">
function GotoURL(dl) {
var val = dl.droplist.value.split(',');
open(val[0], val[1]);
}
</script>
</form>
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