One approach would be to define the rich tooltip as a hidden DIV anywhere on the page, and give it a unique ID. Then, extend the "rev" attribute of the thumbnail image so you can supply that ID to the script and have it reveal the description when the enlarged image is shown. For example:
Code:
<a href="http://www.nasa.gov/images/content/167040main_image_feature_738_ys_4.jpg" rel="enlargeimage" rev="targetdiv:loadarea,descid:galaxy" title="The Universe is just waiting to be explored">Saturn #1</a>
And the description markup itself:
Code:
<div id="galaxy" style="display:none">Deep sky surveys show that galaxies are often found in relatively close association with other galaxies. Solitary galaxies that have not significantly interacted with another galaxy of comparable <a href="#">mass</a> during the past billion years are relatively scarce.</div>
You'll need to use the modified .js file attached in order for all of this to work.
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