If I got your picture right this might be what you want:
HTML Code:
<frameset cols="*,900,*">
<frame src="http://www.google.com/" scrolling="no" />
<frameset rows="107,*">
<frame src="http://www.google.com/" scrolling="no" />
<frameset cols="355,*">
<frameset rows="200,300,*">
<frameset cols="190,*">
<frame src="http://www.google.com/" scrolling="no" />
<frame src="http://www.google.com/" scrolling="no" />
</frameset>
<frame src="http://www.google.com/" scrolling="no" />
<frame src="http://www.google.com/" scrolling="no" />
</frameset>
<frame src="http://www.google.com/" scrolling="no" />
</frameset>
</frameset>
<frame src="http://www.google.com/" scrolling="no" />
</frameset>
I had to add a couple of frames, like next to the 190px wide frame but if you want the big blue part in one piece you'll have to use two iframes instead.
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