Hmm there's no reason why it wouldn't work. Using the HTML for the demo found on DD:
Code:
<a href="http://www.nasa.gov/images/content/167040main_image_feature_738_ys_4.jpg" rel="enlargeimage::mouseover" rev="loadarea::http://www.dynamicdrive.com" title="This is an example">Thumbnail Example 1</a><br />
<a href="http://www.nasa.gov/images/content/168177main_image_feature_749_ys_4.jpg" rel="enlargeimage::mouseover" rev="loadarea">Thumbnail Example 2</a><br />
<a href="http://www.nasa.gov/images/content/166615main_image_feature_733_ys_4.jpg" rel="enlargeimage::click" rev="loadarea2">Thumbnail Example 3 (click)</a><br />
<a href="http://www.nasa.gov/images/content/168291main_image_feature_750_ys_4.jpg" rel="enlargeimage::click" rev="loadarea2">Thumbnail Example 4 (click)</a><br /><br />
<div id="loadarea" style="width: 600px">
<img src="http://www.nasa.gov/images/content/167040main_image_feature_738_ys_4.jpg" />
</div>
<h2 />
<div id="loadarea2" style="width: 550px"></div>
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