That actually is a script like Image Thumbnail Viewer II being used inside of a frameset and could be done using Image Thumbnail Viewer II inside of a frameset.
All you would need to do (once you setup your frameset) is add onclick events to the triggers (the circles on the example page) to load the larger image into the frame, for example:
Code:
<a href="some.jpg" rel="enlargeimage::mouseover" rev="loadarea::http://www.dynamicdrive.com" title="This is an example" onclick="parent.window.frames['main'].location='some_bigger_jpg.htm';return false;"><img src="circle.gif"></a>
Where 'main' is the name of the frame this and the Image Thumbnail Viewer II is in and that you want to fill with the page containing the larger image.
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