While this may be possible, you might want to find a different solution. Having an iframe cover elements of a page is probably possible, but would be limited to certainly new browsers, if not only a few new browsers.
There are ways to make popups of things in the page, not frame, but divs, etc. Some scripts here on DD will do that.
In the end, you might just want a popup window; that would be easier and more compatible.
I'm guessing that you have figured out some way to display the presentation in the iframe, but it might be better to figure out a new way not needing an iframe.
Someone else can probably tell you the code for the frame, but I just am not sure how easy that will be to make work for enough people.
Please post a link to the page on your site that contains the problematic script so we can check it out.
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